3-phytase
| 3-phytase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.8 | ||||||||
| CAS no. | 37288-11-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme 3-phytase (EC 3.1.3.8) catalyzes the reaction
The enzyme characterised from Aspergillus ficuum hydrolyses phytic acid to inositol pentakisphosphate and orthophosphate.[1][2] A genetically modified form of the enzyme has been evaluated for its safety in food manufacture.[3]
These enzymes belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name myo-inositol-hexakisphosphate 3-phosphohydrolase. Other names in common use include 1-phytase, phytate 1-phosphatase, phytate 3-phosphatase, and phytate 6-phosphatase.[4]
Enzymes of this type participate in inositol phosphate metabolism.
Structural studies
[edit]As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1CVM, PDB: 1IHP, PDB: 1POO, PDB: 1QFX, PDB: 1QLG, PDB: 1QWO, PDB: 1SK8, PDB: 1SK9, PDB: 1SKA, PDB: 1SKB, PDB: 2GFI, and PDB: 2POO.
See also
[edit]- 4-phytase (6-phytase)
- 5-phytase
- Protein tyrosine phosphatase
References
[edit]- ↑ Irving, G. C. J.; Cosgrove, D. J. (1972). "Inositol Phosphate Phosphatases of Microbiological Origin: The Inositol Pentaphosphate Products of Aspergillus ficuum Phytases". Journal of Bacteriology. 112 (1): 434–438. doi:10.1128/JB.112.1.434-438.1972. PMC 251429. PMID 4342816.
- ↑ Mullaney EJ, Ullah AH (December 2003). "The term phytase comprises several different classes of enzymes". Biochemical and Biophysical Research Communications. 312 (1): 179–84. Bibcode:2003BBRC..312..179M. doi:10.1016/j.bbrc.2003.09.176. PMID 14630039.
- ↑ Lambré, Claude; Barat Baviera, José Manuel; Bolognesi, Claudia; et al. (2024). "Safety evaluation of the food enzyme 3-phytase from the genetically modified Aspergillus niger strain NPH". EFSA Journal. 22 (1) e8514. doi:10.2903/j.efsa.2024.8514. PMC 10784861. PMID 38222927.
- ↑ Enzyme 3.1.3.8 at KEGG Pathway Database.
